Peptide Synthesis Process

Technical Design Analysis

LabAt Pepceuticals we employ a range of methods to evaluate difficult peptides before synthesis.  In doing so, we can successfully deliver peptide projects, faster.

  • Hydrophobicity plots – used to determine difficult stretches of amino acids in peptides
  • Peptide stability / solubility – insolubility arises when the combined inter-/ intra-peptide ionic and hydrophobic interactions offset favourable peptide-solvent interactions
  • Aggregation potential – a statistical analysis method which is used to determine which amino acid residues are likely to aggregate during peptide synthesis, leading to the formation of truncated peptide fragments
  • Secondary structure formation – it is important to identify secondary structures formed during peptide synthesis.  Using results of analysis we can employ synthetic protocols to disrupt their formation
  • Molecular modelling – a computation technique that allows us to look at the theoretical 3-dimensional structures of peptides.  With this technique we can predict problematic amino acid stretches contained within peptides, thus allowing us to design the peptide strategy more effectively