Natural and un-natural modifications
At Pepceuticals we are able to modify peptides to incorporate a range of moieties or stereocentres, some of which are listed in the table below. Our staff is comprised of fully trained synthetic chemists, we are able to consider any chemically feasible adjustments to the peptide sequence.
| N-Terminal | Internal | C-Terminal |
| Acetylation | Biotin | Amidation |
| Biotinylation | Dabcyl | Aldehydes |
| Cinnamoylation | Dabsyl | 7-Methoxycoumarin |
| Dabcyl | Dansyl | Lysine[Biotin] |
| Dansyl | Fluoroscein | Lysine[Flouroscein] |
| Dinitrophenyl | Dehydro amino acids | Pegylation |
| Flouroscein | Hydroxproline | Rhodamine TAMRA |
| Fmoc | Citrulline | Chloromethylketone |
| Formyl | Homoarginine | p-nitronilide |
| Myristoylation | Lysine[Me] | N-methylamide |
| N-methyl | Ltsine[Me2] | Monomethylarginine |
| Palmitoylation | Lysine[Me3] | Dimethylarginine (SDMA / ADMA) |
| Steroylation | Arginine[Me] | Peptide nucleic acid (PNA) |
| 7-Methoxycoumarin | Aminohexanoyl | |
| FITC | Reduced bond |
This list of modifications is not exhaustive; please enquire if you have a specific modification. |
| KLH | 15N labelled | |
| Pyroglutamoyl | 13C labelled | |
| BOC | Aminohexanoic acid | |